MENÜ MENÜ  

cover

Synthetic cannabinoids in drug discovery. Design, synthesis and evaluation of modified coumarins as CB receptor ligands

Beiträge zur organischen Synthese, Bd. 88

Florian Mohr

ISBN 978-3-8325-5103-2
354 pages, year of publication: 2020
price: 52.50 €
Synthetic cannabinoids in drug discovery. Design, synthesis and evaluation of modified coumarins as CB receptor ligands
The endocannabinoid system represents a highly complex lipid-based (neuro-) transmitter system and can be found in nearly all animals. Since the discovery of the two main cannabinoid receptors CB1 and CB2 in the early '90, intensive research reviled a substantial influence of this system on many physiological and pathophysiological processes. Direct and selective targeting of the system bears a huge potential for the development of novel therapeutic approaches, especially for the treatment of chronical pain, inflammation or other neurological disorders. Therefore, the endocannabinoid system is a promising target in drug development.

In the presented thesis, the design, syntheses and pharmacologic evaluation of substituted coumarins as potential new drug candidates as selective synthetic cannabinoids were investigated. In a combinatorial synthetic approach, several new libraries of new ligands were synthesised and subsequently pharmacological tested.

Additionally, in a second project, novel reversible monoacylglycerol lipase (MAGL) inhibitors have been synthesized and pharmacologically evaluated. Thereby, several important structure-activity relationships for high potency or selectivity were found. Nearly all potencies of the developed inhibitors were determined in the nanomolar regions.

cover cover cover cover cover cover cover cover cover
Table of contents (PDF)

Keywords:

  • Synthetic cannabinoids
  • GPCR
  • cannabinoid receptor
  • drug discovery
  • MAGL

BUYING OPTIONS

52.50 €
in stock

45.50 €
62.50 €
69.00 €

(D) = Within Germany
(W) = Abroad

You can purchase the eBook (PDF) alone or combined with the printed book (Bundle). In both cases we use the payment service of PayPal for charging you - nevertheless it is not necessary to have a PayPal-account. With purchasing the eBook or eBundle you accept our licence for eBooks.

For multi-user or campus licences (MyLibrary) please fill in the form or write an email to order@logos-verlag.de