MENÜ MENÜ  

cover

Dynamics of the IL-2 cytokine network and T-cell proliferation

Dorothea Busse

ISBN 978-3-8325-2693-1
115 Seiten, Erscheinungsjahr: 2010
Preis: 35.50 €
Dynamics of the IL-2 cytokine network and T-cell proliferation
This book adds to a intensively investigated question of immunological research. How do regulatory T cells mediate their function to ensure tolerance against self-antigen? The author analyzes the interaction via the cytokine interleukin 2 between T helper cells, which mediate immune responses, and regulatory T cells. Since both cell types depend on interleukin 2 to mediate their functions, competition for interleukin 2 is likely. A mathematical model is developed to describe the interaction.

This model focuses on the interleukin 2 receptor dynamics on helper and regulatory T cells and the extracellular interleukin 2 diffusion. The interleukin 2 receptor dynamics is governed mainly by an autocrine positive feedback loop on both cell types. However, its differential regulation results in a switch-like up-regulation of the receptors on T helper cells and a gradual adaptation of the receptor levels to extracellular interleukin 2 supply on regulatory T cells. This difference enables regulatory T cells to efficiently compete for interleukin 2 and deprive T helper cells of their growth factor. Cell culture experiments verify these findings. It can be shown that the antigen stimulus and the intercellular distance are relevant control parameters for competition. Other mechanisms are described for suppression of T helper cell action by regulatory T cells; competition for interleukin 2 may act in concert with them.


Wollen auch Sie Ihre Dissertation veröffentlichen?

cover cover cover cover cover cover cover cover cover
Keywords:
  • regulatory T cells
  • mathematical model
  • competition
  • interleukin 2

KAUFOPTIONEN

35.50 €
auf Lager
Versandkostenfrei innerhalb Deutschlands

34.00 €
45.50 €
49.50 €

(D) = innerhalb Deutschlands
(W) = außerhalb Deutschlands

Sie können das eBook (PDF) entweder einzeln herunterladen oder in Kombination mit dem gedruckten Buch (Bundle) erwerben. Der Erwerb beider Optionen wird über PayPal abgerechnet - zur Nutzung muss aber kein PayPal-Account angelegt werden. Mit dem Erwerb des eBooks bzw. Bundles akzeptieren Sie unsere Lizenzbedingungen für eBooks.

Bei Interesse an Multiuser- oder Campus-Lizenzen (MyLibrary) füllen Sie bitte das Formular aus oder schreiben Sie eine email an order@logos-verlag.de